Teresa Ann Murray, PhD
Director, Principal Investigator
Integrated Neuroscience and Imaging Lab
We identify mechanisms of and test therapies for brain injuries, neurological disorders, and neuro-cardiovascular diseases with emphases on changes in cellular morphology, network function, and inflammation over time in the same rodents. In doing so, we have developed novel tools for in vivo, longitudinal imaging, neurochemical recording, and behavioral analysis. Using our longitudinal approach, we normalize measurements to preinjury baseline data, which reduces experimental variability and the numbers of animals required for a study; it also permits unparalleled comparisons between treatment conditions, the elucidation of time windows for the sequelae of pathological processes, and the timing of therapeutic effects over weeks or months.
Our research includes longitudinal studies of:
inflammation and microcirculation in secondary injury associated with traumatic brain injury and stroke and the effects of novel therapies,
the connection between nicotinic acetylcholine receptors and Alzheimer's disease,
design and testing of novel neurochemical probes for chronic use, and
continuous intracortical and subcortical EEG recordings in epileptic rats to predict seizures and explain the network mechanisms of memory loss.
We are funded by the National Institutes of Health, National Science Foundation (BRAIN Initiative), and private foundations.
Murray lab publications and grants: click here for ORCID list.